Combatting intracellular pathogens using bacteriophage delivery

Intracellular pathogens reside in specialised compartments within the host cells restricting access of antibiotics. Insufficient intracellular delivery antibiotics along with several other resistance mechanisms weaken efficacy current therapies. An alternative to antibiotic therapy could be bacteriophage (phage) therapy. Although phage has been practice for a century against various bacterial infections, phages bacteria is still being explored. In this review, we will discuss advancement and challenges therapy, particularly pathogens. Finally, highlight uptake approaches overcome bacteria.